Bill received B.S. degrees in Biochemistry/Biophysics and Crop Science from OSU and his MD from Harvard Medical School. He then completed internship, residency, fellowship, and postdoctoral laboratory training at UCSF. In 1994 he joined the faculty at the University of Pennsylvania Institute for Human Gene Therapy where he established his research laboratory prior to returning to Oregon as Associate Professor of Medicine, Molecular Medicine, and subsequently, Cell Biology, Biochemistry and Molecular Biology at OHSU. There, his research focused on principles of membrane protein biogenesis and quality control, the molecular pathogenesis of cystic fibrosis, and small molecule correction of mutant CFTR proteins. He was elected into the American Society for Clinical Investigation in 2000 and has published nearly 100 scientific papers.
In 2014 Bill joined the Cystic Fibrosis Foundation in Bethesda MD, ultimately becoming Executive Vice President and Chief Scientific Officer. At CFF he was responsible for funding hundreds of CF research labs around the world and building a robust venture philanthropy portfolio that brought together scientists, biotech, pharma, and venture partners to develop new life-saving drugs and ultimately a genetic cure for people with CF. Working with both large and small industry groups, he established and help fund dozens of collaborations for CF drug discovery and development, overseeing a total budget of more than $100M per year. He also continued to run a small research laboratory studying fundamental aspects of CFTR folding and trafficking.
He stepped down as CSO in 2022, and returned to his roots in Oregon where he now lives on a small Douglas Fir tree farm in Salem. When he is not working in his garden, orchard, or young forest, he continues independent consulting activities to help develop cures for rare genetic diseases.