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Ryan Mueller in front of shrubbery

Ryan S. Mueller

Associate Professor
Department of Microbiology

Ryan S. Mueller

Associate Professor
Department of Microbiology

Background

Education

Ph.D., University of California, San Diego

Research

I am interested in using inter-disciplinary approaches to study interactions of microorganisms with natural communities. By applying emerging and traditional molecular biology and optics methods (e.g., -omics, genetics, epifluorescence and confocal laser scanning microscopy), I am attempting to define the molecular mechanisms underlying evolutionary and ecological processes occurring within these communities.horizontal gene transfer mueller I received my Ph.D. from University of California, San Diego in Professor Douglas Bartlett's lab where I studied the molecular traits of the waterborne pathogen Vibrio cholerae that enable its survival within different niches of marine reservoirs. After graduating, I completed a postdoc with Prof. Jill Banfield at the University of California, Berkeley. This research involved using high-throughput genomic, mass spectrometry (MS)-based proteomic, and metabolomic techniques to gain insight into in situ molecular adaptations of microbial communities as environmental conditions change. At the CEAB, I was involved in a project to examine how patterns of microbial community diversity (defined by 165 pyrosequencing) in alpine lakes related to a variety of factors including spatial, seasonal, climatic, physical and chemical variables.

Research Interests

  • Horizontal Gene Transfer
  • Nutrient Cycling
  • Environmental Succession
  • Niche Adaptation
  • Physiological Adaptation to Environmental Change

Publications

  • Trang, T.H. Nguyen, Myrold, D.D. and Mueller, R.S. 2019. Distributions of extracellular peptidases across prokaryotic genomes reflect phylogeny and habitat. Front. Microbiol. doi.org/10.3389/fmicb.2019.00413.
  • Dreher, T.H., Collart, L.P., Mueller, R.S., Halsey, K.H., Bildfell, R.J. Schreder, P., Sobhakumari, A., and Ferry, R. 2018. Anabaena/Dolichospermum as the source of lethal microcystin levels responsible for a large cattle toxicosis event. Elsevier/Toxicon: X; 1:100003.
  • Smith, A.R., Kieft, B., Mueller, R., Fisk, M.R., Mason, O.U., Popa, R., and Colwell, F.S. 2018. Carbon fixation and energy metabolisms of a subseafloor olivine biofilm. The ISME J. https://doi.org/10.1038/s41396-019-0385-0.
  • Guo, X., Li, Z., Yao, Q., Mueller, R.S., Eng, J.K., Tabb, D.L., Hervey, W.J. 2018. Sipros ensemble improves database searching and filtering for complex metaproteomics. Bioinformatis 34(5):795-802.
  • Crump, B.C., Wojahn, J.M., Tomas, F., and Mueller, R.S. 2018. Metatranscriptomics and amplicon sequencing reveal mutualisms in seagrass microbiomes. Frontiers in Microbiol. 9:388.
  • Kieft, B., Zhou, L., Bryson, S., Crump, B., Hettich, R., Chongle, P, Xavier, M. and Mueller, R. 2018. Microbial community structure-function relationships in Yaquina Bay Estuary reveal spatially distinct carbon and nitrogen cycling capacities. Front Microbiol. 9:1282.
  • Kehlet-Delgado, H., Richards, G.P., Häse, C. and Mueller, R.S. 2017. Three draft genome sequences of Vibrio coralliilyticus strains isolated from bivalve hatcheries. Genome Announcements 5(41).
  • Guo, X., Li, Z., Biswas, A., Yao, Q., Mueller, R.S., Eng, J.K., Tabb, D.L., Hervey IV, W.J., and Pan, C. 2017. Ensemble learning improves database searching and filtering for complex metaproteomics. Bioinformatics, in revision.
  • Bryson, S., Li, Z., Chavez, F., Weber, P.K., Pett-Ridge, J.P., Hettich, R.L., Pan, C., Mayali, X., and Mueller, R.S. 2017. Phylogenetically conserved resource partitioning in the coastal microbial loop. ISMEJ, in press.
  • Bryson, S., Li, Z., Pett-Ridge, J., Hettich, R.L., Mayali, X., Pan C., and Mueller, R.S. 2016. Proteomic-based stable isotope probing reveals taxonomically conserved patterns in amino acid assimilation by coastal marine bacterioplankton. mSystems 1(2).