Maude M. David
Maude M. David
She received her PhD in 2010 from the Ecole Centrale de Lyon, University of Lyon, France, with Prof. T.M. Vogel, on the origin of the dehalogenases and bioremediation of chlorinated solvent. Her grad-school work focused on the bacterial adaptation to chlorinated compounds at the genome (evolution mechanisms) and community (bioremediation) level. After graduation, she became a post-doctoral fellow at Lawrence Berkeley National Laboratory with Prof. Janet Jansson. Her work looked at the impact of climate change on soil microbial ecology and specifically at how altered precipitation affect carbon cycle using meta-“omics” analysis of microbial carbon cycling responses. In 2014, she started to work on the impact of the gut microbiome in autism in 2014 with Dennis Wall at Stanford School of Medicine, where she also worked on evolutionary constraints on human genome. She started as an assistant professor at Oregon State University in January 2018. Her expertise lays in microbiology, bioinformatics and genomics, using machine learning and multivariate analysis in order to integrate metagenomics, metatranscriptomics and metaproteomics and understand microbial community functions.
Ph.D. Ecole Centrale de Lyon, U. of Lyon, France
Dr. Maude David's laboratory studies the gut-brain axis, to understand how microbes can impact our behavior, specifically in Autism Spectrum Disorder and Anxiety. She uses a crowd-sourced approach to collect lifestyle type information, diet habits, and samples. Her team is also working on identifying bottlenecks in microbial ecology and bioinformatics, bringing novel solutions to unravel microbial molecular mechanisms by optimizing new molecular methods and improving massive sequencing data annotation.
- Computational Biology
- Microbiome Ecology
- Bioinformatics and Genomics
Research AreaBiomedical Science
- David, M.M., Tataru, C., Daniels, J., Schwartz, J., Keating, J., Hampton-Marcell, J., Gottel, N., Gilbert, J.A. and Wall, D.P. 2018. Crowdsourced study of children with autism and their typically developing siblings identifies differences in taxonomic and predicted function for stool-associated microbes. bioRxiv:319236.
- Kimbrel, J.A., Ballor, N., Wu, Y.W., David, M.M., Hazen, T.C., Simmons, B.A., Singer, S.W. and Jansson, J.K. 2018. Microbial Community Structure and Functional Potential Along a Hypersaline Gradient. Front Microbiol. 9:1492.
- Diaz-Beltran, L., Esteban, F.J., Varma, M., Ortuzk, A., David, M. and Wall, D.P. 2017. Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes. BMC Genomics 19(1):315.
- David, M.M., Enard, D., Ozturk, A., Daniels, J., Jung, J.Y., Diaz-Beltran, L., and D.P. Wall. 2016. Comorbid analysis of genes associated with autism spectrum disorders reveals differential evolutionary constraints. 2016. PloS ONE 11(7)e0157937.
- Hultman, J., Waldrop, M.P., Mackelprang, R., David, M., McFarland, J., Blazewicz, S.J., Harden, J., Turetsky, M.R., McGuire, A.D., Shah, M.B., VerBerkmoes, N.C., Lee, L.H., Mavrommatis, K., and Jansson, J.K. 2015. Multi-omics of permafrost, active layer and thermokarst bog soil microbiomes. Nature 521(7551):208-212.
- Sochat, V., David, M., and Wall, D.P. 2015. Translational meta-analytical methods to localize the regulatory patterns of neurological disorders in the human brain. AMIA Ann. Symp. Proc. 2015, 2073.
- David, M.M., Cecillon, S., Warne, B., Prestat, E., Jansson, J.K., and Vogel, T.M. 2015. Microbial ecology of chlorinated solvent biodegradation. Environ. Microbiol. 17(12):4835-4850.
- Prestat, E., David, M.M., Hultman, J., Tas, N., Lamendella, R., Dvornik, J., Mackelprang, R., Myrold, D.D., Jumpponen, A., Tringe, S.G., Holman, E., Mavromatis, K. and Jansson, J.K. 2014. FOAM (Functional Ontology Assignments for Metagenomes): A hidden Markov Model (HMM) database with environmental focus. Nucleic Acids Res. 42(10):e145-e145.
- Bravo, D., Martin, G., David, M.M., Cailleau, G., Verrecchia, E. and Junier, P. 2013. Identification of active oxalotrophic bacteria by Bromodeoxyuridine DNA labeling in a microcosm soil experiment. FEMS Microbiol. Letts. 348(2):103-111.
- Nicora, C.D., Anderson, B.J., Callister, S.J., Norbeck, A.D., Purvine, S.O., Jansson, J.K., Mason, O.U., David, M., Jurelevicius, D., Smith, R.D. and Lipton, M.S. 2013. Amino acid treatment enhances protein recovery from sediment and soils for metaproteomic studies. Proteomics 13(18-19):2776-2785.
- Mackelprang, R., Waldrop, M.P., DeAngelis, K.M., David, M.M., Chavarria, K.L., Blazewicz, S.J., Rubin, E.M., and Jansson, J.K. 2011. Metagenomic analysis of a permafrost microbial community reveals a rapid response to thaw. Nature 480 (7377):368-371.