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Dipankar Koley in front of black backdrop

Dipankar Koley

Associate Professor
Department of Chemistry

Dipankar Koley

Associate Professor
Department of Chemistry

Background

Education

Postdoctoral Associate (2011 - 2013) University of Michigan - Ann Arbor

Ph.D. (2011) University of Texas - Austin;

M. S. (2005) Texas A&M University - Commerce;

Research

Our group is highly interdisciplinary in the nature of our research efforts. Our main focus is to develop novel electrochemical techniques to investigate new frontiers in microbiology, such as the social behavior of microbes, otherwise known as quorum sensing. This collective behavior of bacteria, or quorum sensing, plays an important role in forming biofilm, which ultimately helps bacteria collectively overcome many adverse environmental conditions, including making the microbes resistant to antibiotics. We are interested in using new electrochemical techniques such as scanning electrochemical microscopy (SECM) to study the microbial metabolites in real-time and in 3D space to elucidate the microbial behavior in the context of biofilm related diseases (cystic fibrosis) and infections in/on biomedical devices (catheters, artificial heart valves etc.). These findings will ultimately lead us to design the next generation smart biomedical devices.

Research Area

Biomedical Science

Publications

  • Ummadi, J. G.; Joshi, V. S.; Gupta, P. R.; Indra, A. K.; Koley, D. Single-Cell Migration as Studied by Scanning Electrochemical Microscopy. Anal. Methods 2015. DOI: 10.1039/C5AY01944C
  • Ren, H.; Colletta, A.; Koley, D.; Wu, J.; Xi, C.; Major, T. C.; Bartlett, R. H.; Meyerhoff, M. E. Thromboresistant/anti-Biofilm Catheters via Electrochemically Modulated Nitric Oxide Release. Bioelectrochemistry 2014, 104C, 10–16. DOI: 10.1016/j.bioelechem.2014.12.003
  • Höfler, L.; Koley, D.; Wu, J.; Xi, C.; Meyerhoff, M. E. Electromodulated Release of Nitric Oxide Through Polymer Material from Reservoir of Inorganic Nitrite Salt. RSC Adv. 2012, 2, 6765–6767. DOI: 10.1039/C2RA20853A
  • Koley, D.; Bard, A. J. Inhibition of the MRP1-Mediated Transport of the Menadione-Glutathione Conjugate (thiodione) in HeLa Cells as Studied by SECM. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 11522–11527. DOI: 10.1073/pnas.1201555109
  • Koley, D.; Ramsey, M. M.; Bard, A. J.; Whiteley, M. Discovery of a Biofilm Electrocline Using Real-Time 3D Metabolite Analysis. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 19996–20001. DOI: 10.1073/pnas.1117298108
  • Liu, X.; Ramsey, M. M.; Chen, X.; Koley, D.; Whiteley, M.; Bard, A. J. Real-Time Mapping of a Hydrogen Peroxide Concentration Profile across a Polymicrobial Bacterial Biofilm Using Scanning Electrochemical Microscopy. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 2668–2673. DOI: 10.1073/pnas.1018391108
  • Koley, D.; Bard, A. J. Triton X-100 Concentration Effects on Membrane Permeability of a Single HeLa Cell by Scanning Electrochemical Microscopy (SECM). Proc. Natl. Acad. Sci. U. S. A. 2010, 3–5. DOI: 10.1073/pnas.1011614107

Awards

  • Robert A Welch Fellowship Grant from Texas A&M University - Commerce
  • Lochte Fellowship Grant from Department of Chemistry in the University of Texas at Austin
  • Travel award from 4th ASM Conference on Cell-Cell Communication in Bacteria, Miami, FL

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