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Bruce Geller sitting in lab

Bruce Geller

Professor Emeritus
Department of Microbiology

Bruce Geller

Professor Emeritus
Department of Microbiology

Background

Education

Ph.D. University of Utah

Research

Research Interests

  • Antisense Antibiotics

Publications

  • Geller, B.L., Li, L., Martinez, F., Sully, E., Sturge, C.R., Dalyt S.M., Pybus, C., and Greenberg, D.E. 2018. Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella penumoniae. J. Antimicrob. Chemother. Mar 1. PMID 29506074.
  • Daly, S.M., Sturge, C.R., Marshall-Batty, K.R., Felder-Scott, C.F., Jain, R., Geller, B.L., and Greenberg, D.E. 2018. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect. Dis. Mar 1. PMID 29461800.
  • Daly, S.M., Sturge, C.R., Felder-Scott, C.F., Geller, B.L., and Greenberg, D.E. 2017. MCR-1 inhibition with peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. MBio. 8(6): pii:e01315-17. doi: 10.1128/mBio.01315-17.
  • Howard, J.J., Sturge, C.R., Moustafa, D.A., Daly, S.M., Marshall-Batty, K.R., Felder, C.F., Zamora, D., Yabe-Gill, M., Labandeira-Rey, M., Bailey, S.M., Wong, M., Goldberg, J.B., Geller, B.L., and Greenberg, D.E. 2017. Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob. Agents Chemother. Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print] PMID: 28137807
  • Otsuka, T., Brauer, A.L., Kirkham, C., Sully, E.K., Pettigrew, M.M., Kong, Y., Geller, B.L., and Murphy, T.F. 2017. Antimicrobial activity of antisense peptide-peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms. J. Antimicrob. Chemother. 72(1):137-144.
  • Sully, E.K., Geller, B.L., Li, L., Moody, C.M., Bailey, S.M., Moore, A.L., Wong, M., Nordmann, P., Daly, S.M., Sturge, C.R., Greenberg, D.E. 2016. Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo. J. Antimicrob Chemother. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print] PMID: 27999041; http://www.kgw.com/news/health/oregon-state-professor-discovers-molecule-to-fight-antibiotic-resistant-bacteria/393736223.
  • Sully, E.K. and Geller, B.L. 2016. Antisense antimicrobial therapeutics. Curr. Opin. Microbiol. 33:47-55.
  • Greenberg, D.E., Sturdevant, D.E., Marshall-Batty, K.R., Chu, J., Pettinato, A.M., Virtaneva, K., Lane, J., Geller, B.L., Porcella, S.F., Gallin, J.I., Holland, S.M., and Zarember, K.A. 2015. Simultaneous host-pathogen transcriptome analysis during Granulibacter bethesdensis infection of neutrophils from healthy subjects and patients with chronic granulomatous disease. Infect. Immun. 83(11):4277-92.
  • Geller, B.L., and Greenberg, D.E. 2014. Peptide-conjugated Phosphorodiamidate Morpholino Oligomers: A New Strategy for Tackling Antibiotic Resistance. Ther. Deliv. 5(3): 243-5.
  • Geller, B.L., Marshall-Batty, K., Schnell, F.J., McKnight, M.M., Iversen, P.L., and Greenberg, D.E. 2013. Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth in vitro and in vivo. J. Infect. Dis.
  • Reese, K.A., Lupfer, C., Johnson, R.C.Mitev, G.M., Mullen, V.M., Geller, B.L., and Pastey, M. 2013. A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza Virus Prolongs Survival of Vaccinated Chickens. Vet. Med. Intl. Article 316926.
  • Puckett, S.E., K.A. Reese, G.M. Mitev, V. Mullen, R.C. Johnson, K.R. Pomraning, B.L. Mellbye, L.D. Tilley, P.L. Iversen, M. Freitag and B.L. Geller. 2012. Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers. Antimicrob. Agents Chemother. 56:6147-6153.
  • Panchal, R.G., B.L. Geller, B. Mellbye, D. Lane, P.L. Iversen and S. Bavari. 2012. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis. Nuc. Acid Therap. 22:305-311.
  • Greenberg, D. E., K. R. Marshall-Batty, L. R. Brinster, K. A. Zarember, P. A. Shaw, B. L. Mellbye, P. L. Iversen, S. M. Holland, and B. L. Geller. 2010. Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia complex. J. Infect. Dis., 201(12):1822-30.
  • Mellbye, B. L., D. D. Weller, J. N. Hassinger, M. D. Reeves, C. E. Lovejoy, P. L. Iversen, and B. L. Geller. 2010. Cationic Phosphorodiamidate Morpholino Oligomers Efficiently Prevent Growth of Escherichia coli in vitro and in vivo. J. Antimicrob. Chemother. 65:98-106.
  • Mitev, G. M., B. L. Mellbye, P. L. Iversen, and B. L. Geller. 2009. Inhibition of Intracellular Growth of Salmonella enterica serovar 1 typhimurium in Tissue. Antimicrob. Agents Chemother. 53:3700-3704.
  • Shen, N., J. Ko, G. Xiao, D. Wesolowski, G. Shan, B. Geller, M. Izadjoo, and S. Altman. 2009. Inactivation of Expression of Several Genes in a Variety of Bacterial Species by EGS Technology. Proc. Natl. Acad. Sci. U.S.A. 106:8163-8168.
  • Mellbye, B. L., S. E. Puckett, L. D. Tilley, P. L. Iversen, and B. L. Geller. 2009. Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo. Antimicrob. Agents Chemother. 53:525-530.
  • Tilley, L., B. Mellbye, S. E. Puckett, P. L. Iversen, and B. L. Geller. 2007. Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugate: Dose-Response in Mice Infected with Escherichia coli. J. Antimicrob. Chemother. 59:66-73.
  • Tilley, L., O.S. Hine, J.A. Kellogg, J.N. Hassinger, D. Weller, P.L. Iversen, and B.L. Geller. 2006. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella typhimurium in Pure Culture and in Tissue Culture. Antimicrob, Agents Chemother. 50: 2789-2796.
  • Geller, B.L., J. Deere, L. Tilley, and P.L. Iversen. 2005. Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis. J. Antimicrob. Chemother. 55:983-988.
  • Deere, J., P. Iversen, and B.L. Geller. 2005 Antisense phosphorodiamidate morpholino oligomer length and target position effect on gene-specific inhibition in Escherichia coli. Antimicrob. Agents Chemother. 49:249-255.
  • Geller, B.L., J.D. Deere, D.A. Stein, A.D. Kroeker, H.M. Moulton, and P.L. Iversen. 2003. Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers. Antimicrob. Agents Chemother. 47:3233-3239.

Presentations

  • Live Press Conference at ASM ICAAC: http://www.microbeworld.org/podcasts/asm-live/asm-live-archives/1764-icaac-2014-new-antimicrobial-strategy-silences-ndm-1-resistance-gene-in-pathogens