Publications

• “Manipulation of the Symbiodiniaceae microbiome influences symbioses and reproductive ecology in the host, Exaiptasia diaphana, over generations” M. McCauley, F. Montesanto, S. Bedgood, C. Miner, K. Plichon, V. M. Weis, S. Loesgen. ISME Journal 2025. Online 09/02/2025 https://doi.org/10.1093/ismejo/wraf189
• “Embryonic Zebrafish Irritant-evoked Hyperlocomotion (EZIH) as a high-throughput behavioral model for nociception” A. A. Bunnell, E. M. Marshall, S. Estes, M. Deadmond, S. Loesgen, J. A. Strother. Behav. Brain Res. 2025, 485, 115526. https://doi.org/10.1016/j.bbr.2025.115526
• “Synthesis, Characterization, Antimicrobial, Cytotoxic and Carbonic Anhydrase Inhibition Activities of Multifunctional Pyrazolo-1,2-Benzothiazine Acetamides” A. Saeed, S. Ehsan, M. Zia-ur-Rehman, E. M. Marshall, S. Loesgen, A. Saleem, S. Giovannuzzi, C. T. Supuran Beilstein J. Org. Chem. 2025, 21, 348-357. https://doi.org/10.3762/bjoc.21.25
• “Total Synthesis of Chalaniline A: An Aminofulvene Fused Chromone from Vorinostat-Treated Fungus Chalara sp. 6661“ P. Prapapongpan, V. Vanthiya, O.-S. Kwon, L. N. Zakharov, S. Loesgen, P. R. Blakemore. J. Org. Chem. 2024, 89, 14601-146-5. Online 09/12/2024. https://doi.org/10.1021/acs.joc.4c01855
• “Early-Stage Biosynthesis of Phenalinolactone Diterpenoids Involves Sequential Prenylation, Epoxidation, and Cyclization” T. Alsup, Z. Li, C. McCadden, A. Jagels, D. Lomowska-Keehner, E. M. Marshall, L.-B. Dong, S. Loesgen, R. D. Rudolf. RSC Chem. Biol. 2024, 5, 1010-1016. DOI: 10.1039/d4cb00138a. Online 08/05/2024.
“Chemical Diversity of Aspergillus alliaceus Phenotypes: Discovery of brominated Bianthrones with triple-negative breast cancer Activity” P. E. Mandelare, S. S. Yee, D. G. Icenhour, E. N. Kaweesa, M. McCauley, A. L. Risinger, J. D. Rudolf, S. Loesgen ChemBioChem 2024 e202400398. Online 07/18/2024. http://dx.doi.org/10.1002/cbic.202400398.
“Computation-guided scaffold exploration of 2E,6E-1,10-trans/cis eunicellanes” Z. Li, S. Jindani, V. Kojasoy, T. Ortega, E. M. Marshall, K. A. Abboud, S. Loesgen, D. J. Tantillo, J. D. Rudolf. Beilstein J. Org. Chem. 2024, 20, 1320-1326. Online: 06/07/2024. https://doi.org/10.3762/bjoc.20.115
“Outlining the Hidden Curriculum: Perspectives on Successfully Navigating Scientific Conferences” E. J. Caro-Diaz, M. J. Balunas, L.-A. Giddings, S. Loesgen, B. T. Murphy, C. B. Naman, C. E. Salomon, K. J. Tidgewell, J. M. Winter. J. Nat. Prod. 2024, 87, 1487-1492. Online 05/24/2024. https://doi:10.1021/acs.jnatprod.3c00867.
“Pyrazinone Biosynthesis and Signaling – Myxo Style’ R. D. Rudolf, S. Loesgen. ACS Cent. Sci. 2024. Online 03/12/2024. https://doi.org/10.1021/acscentsci.4c00356
“Fungal endophytes from Thalassia testudium show bioactivity against the seagrass pathogen Lybyrinthula spp.” K. Ugarelli, A. Jagels, C.-J. Choi, S. Loesgen, U. Stingl. Front. Mar. Sci. 11 2024. Online 03/11/2024 https://doi.org/10.3389/fmars.2024.1359610
“Multicellular species environmental DNA (eDNA) research constrained by overfocus on mitochondrial DNA Environmental (e)DNA research constrained by overfocus on mitochondrial DNA” M. McCauley, S. A. Koda, S. Loesgen, D. J. Duffy. Sci. Total. Environ. 2024, 912, 169550. https://doi.org/10.1016/j.scitotenv.2023.169550
“A novel eDNA approach for rare species monitoring: application of long-read shotgun sequencing to Lynx rufus soil pawprints” S. A. Koda, M. McCauley, J. A. Farrell, I. Duffy, F. Duffy, S. Loesgen, J. Whilde, D. J. Duffy. Biological Conservation 2023, 287, 110315. https://doi.org/10.1016/j.biocon.2023.110315
“Systematic review of cnidarian microbiomes reveals insights into the structure, specificity, and fidelity of marine associations” M. McCauley, T. L. Goulet, C. R. Jackson, S. Loesgen. Nat. Commun. 14, 4899, 2023, online 08/14/2023. https://doi.org/10.1038/s41467-023-39876-6
“Metabolomics-guide discovery, isolation, structure elucidation, and bioactivity of myropeptins C-E from Myrothecium inundatum” A. Jagels, D. A. Adpressa, E. N. Kaweesa, M. McCauley, B. Philmus, J. A. Strother, S. Loesgen. J. Nat. Prod. 2023. https://doi.org/10.1021/acs.jnatprod.3c00148
“First trans-eunicellane terpene synthase in bacteria’ Z. Li, B. Xu, T. Ortega, D. A. Adpressa, W. Ning, X. Wei, J. Liu, D. J. Tantillo, S. Loesgen, J. D. Rudolf. Chem 2023, 3, 698-708. https://doi.org/10.1016/j.chempr.2022.12.006
“The natural product mensacarcin combats BRAF mutant and chemo-resistant melanoma by affecting cell metabolism and cellular migration“ E. N. Kaweesa, A. Padhi, G. N. Davis, R. P. McMillan, D. A. Brown, A. S. Nain, S. Loesgen. Advances in Cancer Biology - Metastasis 2022, 6, 10070. https://doi.org/10.1016/j.adcanc.2022.100070
"Heat stress of the algal partner hinders colonization success and alters the algal cell surface glycome in acnidarian-algal symbiosis" S. Maruyama, P. E. Mandelare-Ruiz, M. McCauley, W. Peng, B. Cho, J. Wang, Y. Mechref, S. Loesgen, V. M. Weis. Microbiol. Spec. 2022, 10 (3), e01567-22. https://doi.org/10.1128/spectrum.01567-22
“Altertoxin II, a highly effective and specific cytotoxin against Ewing sarcoma” A. J. Robles, W. Dai, S. Haldar, H. Ma, V. Anderson, R. D. Overacker, A. L. Risinger, S. Loesgen, P. J. Houghton, R. H. Cichewicz, S. L. Mooberry. Cancers 2021, 13(24), 6176, https://doi.org/10.3390/cancers13246176
“Precursor-directed biosynthesis of aminofulvenes: new chalanilines from endo phytic fungus Chalara sp.” M. Khoshbakht, J. Srey, D. A. Adpressa, A. Jagels, S. Loesgen. Molecules 2021, 26(15), 4418; https://doi.org/10.3390/molecules26154418
“Comparative Genomics of eight Fusarium graminearum strains with contrasting aggressiveness reveals an expanded open pangenome and extended effector content signatures“. T. Alouane, H. Rimbert, J. Bormann, G. A. González-Montiel, S. Loesgen, W. Schäfer, M. Freitag, T. Langin*, L. Bonhomme* Int. J. Mol. Sci. 2021, 22, 6257. https://doi.org/10.3390/ijms22126257
“Total Synthesis of Chalaniline B: An Antibiotic Aminoxanthone Isolated from Vorinostat-Treated Fungus Chalara sp. 6661”. M. Khoshbakht, B. Thanaussavadate, C. Zhu, Y. Cao, L. N. Zakharov, S. Loesgen, P. R. Blakemore* J. Org Chem. 2021, 86, 7773-7780. DOI:10.1021/acs.joc.1c00528
“Discovery and biosynthesis of a structurally dynamic antibacterial diterpenoid”. C. Zhu§, B. Xu§, D. A. Adpressa§, J. D. Rudolf*, S. Loesgen* Angewandte Chemie 2021, 60, 14163-14170. DOI: 10.1002/anie.202102453R1 and 10.1002/ange.202102453R1
“Biodiversity, bioactivity, and metabolites of high desert derived Oregonian soil bacteria” C. Zhu, C. I. Lew, G. F. Neuhaus, D. A. Adpressa, L. N. Zakharov, E. N. Kaweesa, B. Plitzko, S. Loesgen*. Chem. Biodiv. 2021, 18, e2100046 DOI https://doi.org/10.1002/cbdv.202100046
“Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores“ . M. -Y. Wu, M. E. Mead, M. -K. Lee, G. F. Neuhaus, D. A. Adpressa, J. I. Martien, Y. -E. Son, H. Moon, D. Amador-Noguez, K. -H. Han, A. Rokas, S. Loesgen, J. -H. Yu, H. -S. Park. mBIO 2021 12 (1): e03128-20. Doi: 10.1128/mBio.03128-20.
“Antibacterial Drimane Sesquiterpenes from Aspergillus ustus“ . G. F. Neuhaus, S. Loesgen* J. Nat. Prod. 2021, 84, 1, 37-45. Doi: 10.1021/acs.jnatprod.0c00910
“Biolayer Interferometry Provides a Robust Method for Detecting DNA-Binding Small Molecules in Microbial Extracts” R. D. Overacker, B. Plitzko, S. Loesgen* Anal. Bioanal. Chem. 2020, 413, 1159-1171. https://doi.org/10.1007/s00216-020-03079-5
“Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus Zasmidium pseudotsugae” G. A. González-Montiel, E. N. Kaweesa, N. Feau, R. C Hamelin, J. K. Stone and Sandra Loesgen* Molecules 2020, 25, 2358; doi:10.3390/molecules25102358
“N-linked surface glycan biosynthesis, composition, inhibition, and function in cnidarian-dinoflagellate symbiosis” T. R. Tivey, J. E. Parkinson, P. E. Mandelare, D. A. Adpressa, W. Pang, X. Dong, Y. Mechref, V. M. Weis, S. Loesgen* Microbial Ecology 2020, 80, 223-236. DOI: 10.1007/s00248-020-01487-9
“Bioenergetics underlying single cell migration on aligned nanofiber scaffolds” A. Padhi, A. H. Thomson, J. B. Perry, G. N. Davis, R. P. McMillan, S. Loesgen, E. N. Kaweesa, R. Kapania, A. S. Nain, D. A. Brown. Am J Physiol Cell Physiol. 2020 Mar 1; 318(3): C476–C485. https://doi.org/10.1152/ajpcell.00221.2019
“Polyketides from marine-derived Aspergillus porosus: challenges and opportunities for determining absolute configuration“. G. F. Neuhaus, D. A. Adpressa, T. Bruhn, S. Loesgen* J. Nat. Prod. 2019, 82, 2780-2789. DOI 10.1021/acs.jnatprod.9b00416 Note: 2020 JNP Jack L. Beal award for best paper by a young investigator
“A metabolomics-guided approach to discover novel Fusarium graminearum metabolites after removal of a repressive histone modification” D. A. Adpressa+; L. R. Connolly+, Z. M. Konkel, G. F. Neuhaus, X. L. Chang; B. R. Pierce, K. M. Smith, M. Freitag*, S. Loesgen* Fungal Genetics and Biology 2019, 132, 103256. DOI:10.1016/j.fgb.2019.103256
“Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline“ R. D. Overacker, S. Banerjee, G. F. Neuhaus, S. Milicevic Sephton, A. Herrmann, J. A. Strother, R. Brack-Werner, P. R. Blakemore, S. Loesgen* Bioorganic & Medicinal Chemistry 2019, 27, 3595-3604. DOI: 10.1016/j.bmc.2019.06.044
“Expression of a structural protein of the mycovirus FgV-ch9 negatively affects the transcript level of a novel symptom alleviation factor and causes virus-infection like symptoms in Fusarium graminearum” J. Bormann, C. Heinze, C. Blum, M. Mentges, A. Brockmann, A. Alder, S. K. Landt, B. R. Josephson, D. Indenbirken, M. Spohn, B. Plitzko, S. Loesgen, M. Freitag, W. Schäfer. J. Virol. 2018, DOI: 10.1128/JVI.00326.18
“Measurement of Oxygen consumption rate (OCR) and Extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism” Birte Plitzko, S. Loesgen*; Bio-protocol 2018 8(10): e2850. DOI: 10.21769/BioProtoc.2850.
“Subtle differences in symbiont cell surface glycan profiles do not explain species-specific colonization rates in a model cnidarian-algal symbiosis” J. E. Parkinson, T. R. Tivey, P. E. Mandelare, D. A. Adpressa, S. Loesgen, V. M. Weis. Front. Microbiol. 2018, 9, 842. DOI: 10.3389/fmicb.2018.00842
“Co-culture of two Developmental Stages of a Marine-derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A” P. E. Mandelare, D. A. Adpressa, E. N. Kaweesa, L. N. Zakharov, S. Loesgen. J. Nat. Prod. 2018, 81, 1014-1022. DOI: 10.1021/acs.jnatprod.8b00024
„The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells“ . B. Plitzko, E. N. Kaweesa, S. Loesgen* J. Biol. Chem. 2017, 51, 21102-21116. DOI:10.1074/jbc.M116.774836
„Unexpected biotransformation of the HDAC inhibitor vorinostat yields aniline-containing fungal metabolites“. D. A. Adpressa, K. J. Stalheim, P. J. Proteau, Sandra Loesgen* ACS Chem. Biol. 2017, 12, 1842-1847. DOI: 10.1021/acschembio.7b00268
“Bioprospecting chemical diversity and bioactivity in a marine derived Aspergillus terreus”, D. A. Adpressa, S. Loesgen*; Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310
“Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8”, S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold*; ChemBioChem, 2014, 15, 749-756.