Sandra Loesgen
Associate Professor
Department of
Chemistry
Connect with Sandra
Gilbert Hall 333 sandra.loesgen@oregonstate.edu (541) 737-1690Research Group Website
Organic and Bioorganic Website
Sandra Loesgen
Associate Professor
Department of
Chemistry
Background
Education
Postdoctoral Fellow, NIH Intramural Research, NIDDK, Bethesda, MD 2011-2013
Postdoctoral Fellow, Scripps Institution of Oceanography, University of California - San Diego 2008-2010
Ph.D. Chemistry, Georg-August University of Gottingen, Germany 2007
Research
My laboratory is principally interested in target-based drug discovery with a focus on (1) identification of genetically encoded, biologically active natural products from microbial sources, (2) developing new screening techniques for small molecules and proteins that inhibit viral cell entry, and (3) using integrated approaches to elucidate the molecular basis of inhibitor interactions with target viral proteins by means of biophysical and structural studies.
Publications
- D.A. Adpressa, S. Loesgen, Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310
- S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.
- A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10-23-2013 DOI: 10.1021/mp400399b.
- M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.
- N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.
- L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.
- G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439
- A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.
- S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.
Awards
- Terence Bradshaw Scholar 2013
- NIH & FDA Thermo Fisher 'Glycobiology of Viruses' Best Poster Award, Bethesda, MD 2012
- National Institutes of Health (NIH) Intramural Research Trainee Award 2011-2013
- German Research Foundation (DFG) Fellowship 2008-2010
